Distribution of 11-Nor-9-Carboxy-Δ9-tetrahydrocannabinol in Traffic Fatality Cases

Distribution of ∆9-Tetrahydrocannabinol and 11-Nor-9-Carboxy-∆9-Tetrahydrocannabinol in Postmortem Biological Fluids and Tissues From Pilots Fatally Injured in Aviation Ac

High-throughput toxicological analysis of Δ9-THC and 11-nor-9-carboxy-Δ9-THC by LC/MS/MS

A new high-throughput liquid chromatography / tandem mass spectrometry (LC-MS/MS) method for the quantification of Δ-tetrahydrocannabinol (THC) in suspect plant material and of its principal metabolite, 11-nor-9carboxy-Δ-tetrahydrocannabinol (THC-COOH), in human urine was developed and validated. The separation was performed on a Zorbax SB-C18 column under isocratic conditions using a mixture o...

Estimating the time of last cannabis use from plasma delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol concentrations.

BACKGROUND Knowing the time cannabis was last used is important for determining impairment in accident investigations and clinical evaluations. Two models for predicting time of last cannabis use from single plasma cannabinoid concentrations-model I, using Delta(9)-tetrahydrocannabinol (THC), and model II, using the concentration ratio of 11-nor-9-carboxy-THC (THCCOOH) to THC-were developed and...

Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana.

Interpretation of marijuana-positive urine tests requires an understanding of the excretion pattern of marijuana metabolites in humans. However, limited urinary excretion data from controlled clinical studies of marijuana use are available. In this study, six subjects smoked a single marijuana cigarette (placebo, 1.75% delta 9-tetrahydrocannabinol [THC], or 3.55% THC) each week while residing o...

Mini - Review 11 - Nor - 9 - carboxy - ∆ 9 - tetrahydrocannabinol – a ubiquitous yet underresearched cannabinoid . A re - view of the literature

Synthetic ∆ 9 -tetrahydrocannabinol (THC), pharmaceutical grade herbal cannabis as well as formulations of well-defined cannabis extracts are available as registered medicines in several countries. It is generally accepted that the main central and peripheral pharmacological effects of THC are mediated by CB1 and CB2 cannabinoid receptors. Cytochrome P450-mediated oxidations of THC afford the n...